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Caspofungin-non-susceptible Candida isolates in cancer patients.
癌症患者中分离到的卡泊芬净不敏感念珠菌株

出处: J Antimicrob Chemother   2010   Feb   65 (2) :293-5

作者:Kofteridis DP;Lewis RE;Kontoyiannis DP

PMID:20016020

OBJECTIVES: To identify the frequency of caspofungin-non-susceptible Candida isolates in cancer patients with candidiasis. METHODS: We reviewed the in vitro susceptibilities (M27-A3 CLSI method) of 650 Candida spp. associated with invasive candidiasis episodes in 582 hospitalized cancer patients (2005-08). RESULTS AND CONCLUSIONS: We identified seven caspofungin-non-susceptible Candida strains (three Candida tropicalis, two Candida glabrata and two Candida albicans) from 650 Candida isolates (1%). C. tropicalis (three out of seven) was the most common non-susceptible species isolated. All patients responded to a change of antifungal therapy. Further surveillance should focus on the potential broader emergence of echinocandin resistance, as the clinical use of this antifungal class continues to expand in cancer patients.

目的:鉴定伴念珠菌病的癌症病人中分离到卡泊芬净不敏感念珠菌株的频率。方法:我们回顾了582名住院癌症患者(2005-08)侵袭性念珠菌病相关的650株念珠菌的体外敏感性(M27- A3临床实验室标准化研究所CLSI法)。结果与结论:650株分离的念珠菌中,我们鉴定出7株(1%)对卡泊芬净不敏感的念珠菌(3株热带念珠菌,2株光滑念珠菌和2株白色念珠菌)。热带念珠菌(7株中的3株)是最常见的非敏感分离菌种。所有患者对抗真菌治疗的更换有反应。进一步的监测应着眼于潜在、广泛出现的棘白菌素耐药性,因为这一类抗真菌药在癌症病人的临床应用不断扩大。