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Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009).
治疗侵袭性真菌病的新型抗真菌药物、治疗靶点及治疗策略:文献综述(2005-2009)

出处: Rev Iberoam Micol   2009   Mar   26 (1) :15-22

作者:Espinel-Ingroff A

PMID:19463273

BACKGROUND: The incidence and prevalence of serious mycoses continues to be a public health problem. Despite aggressive treatment with new or more established licensed antifungal agents, these infections are an important cause of morbidity and mortality, especially in immunocompromised patients. AIMS: To critically review the literature regarding important new developments in the field of antifungal therapy both in the English and Spanish versions. METHODS: The search of the literature focused on different antifungal targets or mechanisms of action as well as new agents or strategies that could improve antifungal therapy. RESULTS: The review produced a huge amount of information on the use of virulent factors such as growth, filamentation, pathogen tissue clearance, among others, as putative targets of antifungal activity. More recently, the chemical-genetic relationships for licensed agents as well as for other compounds have been provided by the identification of the genes related to the mechanism of action. CONCLUSIONS: Although the antifungal activity of numerous compounds has been examined, most of them are at the in vitro or animal models of efficacy stages. Therefore, further investigation should be carried out to realize the true clinical utility of these compounds.

背景:严重真菌病的发生率和流行依旧是公共卫生的一个难题。尽管可用新型或许多已获许可的抗真菌药物进行积极治疗,但这类感染仍是发病和死亡的重要原因,对免疫功能低下的患者尤其如此。目的:批判性综述有关抗真菌治疗领域内英语和西班牙语的重要新进展文献。方法:重点查找有关不同的抗真菌作用靶点或作用机制及能改进抗真菌治疗的新药物或新策略方面的文献。结果:综述获得了大量有关使用生长、丝化现象、病原组织清除或其它毒力因子作为抗真菌治疗假定靶点方面的信息。最近,与作用机制相关基因的发现为已获许可药物及其它化合物提供了化学与基因间的联系。结论:尽管多种化合物的抗真菌活性已被检测,但其中大多数处于体外或动物模型疗效阶段。因此,应该进行进一步的研究以了解这些化合物的真正临床功效。